- Title
- Zinc supplementation in pre-diabetes mellitus: a systematic review and meta-analysis.
- Creator
- Jayawardena, Ranil; Ranasinghe, Priyanga; Kodithuwakku, Wasana; Dalpatadu, Chamila; Attia, John
- Relation
- Minerva Endocrinology Vol. 2021, Issue Mar 16
- Publisher Link
- http://dx.doi.org/10.23736/s2724-6507.21.03234-x
- Publisher
- Edizioni Minerva Medica
- Resource Type
- journal article
- Date
- 2021
- Description
- NTRODUCTION: Certain pharmacological and lifestyle interventions have been shown to reduce progression of pre-diabetes. We aimed to perform a systematic review and meta-analyses of studies assessing the outcomes of zinc supplementation in individuals with pre-diabetes. EVIDENCE ACQUISITION: A comprehensive search was conducted in PubMed, SciVerse Scopus and Web of Science databases. Controlled clinical trials in pre-diabetics, on zinc supplement with or without other nutrients, assessing at least one accepted glycaemic parameter as an outcome were deemed eligible. EVIDENCE SYNTHESIS: Three papers were included in the systematic review and meta analysis, with a total of 265 participants. Duration of zinc supplementation ranged from 6-12 months. The zinc dose ranged from 20-30 mg/day. In the pooled analysis, zinc supplementation significantly reduced FBG both when given alone (-10.86 mg/dL; 95% CI, -14.74 to -6.98; p<0.001) and with other micronutrients (-11.77 mg/dL; p<0.001). Similarly, 2hr-OGTT blood glucose was reduced by 21.08 mg/dL (95% CI, -40.05 to -2.11; p=0.03) in the pooled analysis of studies using zinc alone and in combination with other micronutrients. One study demonstrated a significant reduction of HbA1c by 0.5% with combined supplementation, while another reported a significant reduction in CRP with zinc supplementation. When all trials were considered, TC, HDL-c and HOMA-β showed significant improvement. Zinc supplementation significantly improved the zinc status from baseline. CONCLUSIONS: Zinc supplementation demonstrated beneficial effects on glycaemic and lipid parameters in individuals with pre-diabetes. It may have the potential to reduce the prevalence of pre-diabetes and control associated morbidity and mortality.
- Subject
- zinc; pre-diabetes; blood glucose; supplementation; clinical trial; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1449550
- Identifier
- uon:43691
- Identifier
- ISSN:2724-6507
- Language
- eng
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